HISTORY OF CANCER

Cancer is a disease that cell growth is not only in humans but also in animals and plants as a result of damage to genes that regulate cell growth and differentiation .

Cancer for the first time discovered in time 125 million years BC Mezozoicum the dinosaur fossil animal bones , but probably only a hemangioma .

Cancer in humans

First human cancers discovered by dr Eugene Dubois ( 1891) . At that time , every bump is considered cancer , treated with surgery using a knife or burned with a hot iron or hot oil is poured . name of cancer

Carcinos name or carcinoma or cancer was first used by Hippocrates , a Greek physician 400 years BC . Penyakt cancer as opposed to benign tumors , such as hemorrhoids and ulcers can be cured Chronis .

Hippocrates described the breast, uterus , stomach , skin and rectum . In theory he presented humeral , he considers the body consists of four essential elements , namely blood (blood ) of the heart , phlegmon of the head , yellow bile ( yellow bile ) from the liver and bile (black bile ) of the spleen . Disease occurs because there is no balance of these elements and in the case of any cancer because too much black bile . At the age of 4 elements Hyppocrates teachings still mendominatsi disease treatment methods.

Anatomy and Surgery was developed by Ambroise Pare (1510-1590) with his book completes oevres ( 1575 )

3 . Bacteriology developed by Antoni van Leeuwenhoek (1635-1723) in the Netherlands . Age - XVII century XIX

In 1700 established the first cancer hospital in Reims , France . At that time the cancer is considered as infectious diseases such as leprosy

1755 Sir Percivall Pott in the UK for the first time demonstrated the presence of substances called carcinogens in chimney soot factories that can cause skin cancer scrotum . Johannes Muller in 1800 in Germany to develop pathology . He showed the cancer network consists of cancer cells

1809 Ephraim MacDonald in America started doing major surgery for cancer viscera were lifted 10kg ovarian tumors

1828 Fredrich Wohler succeeded mensintese Ureum an organic substance in the laboratory from a substance inorganic nitrogen , which reveals about the origin of living things from inorganic substances

Scheiden Swan plants and an expert anatomist von Mohl and developed the theory of the cell and protoplasm

 2 . 1859 Charles Darwin ( 1809-1875 ) put forward the theory of the origin of living things and keturunanannya through evolution and natural selection . 1866 De Vries ( 1848-1935 ) put forward the theory of genes that give rise to varieties of living things

1884 In New York established the first cancer hospital which later ( 1899) called Memorian Cancer Hospital

1894 William Steward Halsteds ( 1852-1922 ) and Willie Meyer ( 1854-1932 ) teaches the basics of en block surgery for cancer and do a radical mastectomy for breast cancer

1895 1 . Cullen and William Welch is first frozen section biopsy advocate for breast cancer diagnostic

2 . Willem Condrad Rontgen (1845-1935) found that X-rays can destroy the cancer cells and within two months began to be used for breast cancer radiation . Marie Curie discover the radioactive elements uranium emit radiation 3 , ie alpha rays (protons), beta rays ( electrons ) and gamma rays ( electromagnetic ) which has the same properties as X-rays and also soon be used in Paris for treatment of skin diseases . Age - XX century

1910 Thomas Hunt Morgan ( 1866-1945 ) discovered the gene that controls the descent properties

Oncogene 1911 found in Rous sarcoma virus .

1913 In the United States established the foundation of cancer ( American Cancer Society )

1920 held the first Papanicolaou cytology test for cervical cancer detection

1930 Sir Ronald Aylmer Fisher said that the gene diversity. 1935 For the first time made ​​cancer registration in Connecticut , USA

Robert McWhirter on 1942 cases of breast cancer advocate simple mastectomy combined with radiological

First discovered in 1947 a remission in the treatment of cancer , namely leukemia in Sidney Faber 's Hospital , Boston uses chemotherapy

1949 Linus Pauling discover the molecular structure of the triplet codon ( genetic code ) to transcribe genetic code . American Cancer Society recommends early detection of breast cancer with breast self-examination . The fact that 90 % of breast cancers in first discovered by sufferers themselves .

2 . 1953 Francois Bacclase ( 1896-1967 ) in breast cancer ( breast cancer ) recommends breast tumor excision followed by radiotherapy

Discovered in 1960 by a Barski hybridoma technique , which combines bacterial genes with humans . Hybridoma technique was later developed into gene engineering to make a monoclonal antibody

1961 Marshall Nirenberg found that a triplet of nucleotides called codon genetic code , can arrange the 64 combinations of proteins by gene

1962 Egan recommends mammography for breast cancer diagnostic

In 1971 the U.S. Congress approved the National Cancer Act

In the 1973 Asian Cancer Conference to - 1 ( 16 September - 21 September 1973), in Tokyo and Japan Shima , formed AFOCC ( Asian Federation of Organization for Cancer research)

The 1974 U.S. Surgeon General 's report on the dangers of smoking which can cause lung cancer in 1950 and lung cancer is the No. 1 killer in America

In America project started in 1975 Breast Cancer Detection Project undertaken nationally by ACS (American Cancer Society ) and NCI (National Cancer Institute)

Itakura 1977 , Hirose and Crea successfully combining human genes with bacterial plasmid E. coli

1980 Olsson and Kaplan managed to create hybridoma derived from the combined myloma cells ( cancer cells from mouse B lymphocytes - mus musculus ) and human lymphocytes which paved the way to make a magic bullet ( magic bullet ) to attack cancer cells . Monoclonal antibody coupled sitostatika or radioisotope that directly attack only cancer cells or without damaging normal cells